The lethal action of aminoglycoside
نویسندگان
چکیده
منابع مشابه
Mechanisms of action of aminoglycoside antibiotics in eucaryotic protein synthesis.
Tetrahymena thermophila is a eucaryotic organism that is highly susceptible to growth inhibition by aminoglycoside antibiotics. Concentrations of paromomycin, gentamicin G418, and hygromycin B at 22, 10, and 17 microM, respectively, inhibited growth by 50%. A combination of in vitro and in vivo methods was used to determine the mechanisms of action of these aminoglycoside antibiotics on protein...
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Thompson, T. L. (University of Nebraska, Lincoln), and J. M. Shively. Lethal action of ribonuclease for thermophilic bacilli. J. Bacteriol 91:673-676. 1966.-Exposure of a thermophilic bacillus, NU 47, to 0.2 mug/ml of pancreatic ribonuclease resulted in a drastic reduction of viable cells. The observed lethality is thought to be associated specifically with the ribonuclease, since heat treatmen...
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Potassium permanganate pills were used by Rogers (1913) in cholera cases to neutralize the toxins of the cholera vibrio, and 'permanganate is commonly used to disinfect clothes, well water and tank water, cholera stools, etc., during an epidemic. Hands also are often washed with permanganate solutions after attending cholera cases. There are various old references to potassium permanganate in d...
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The aminoglycosides, a group of structurally related antibiotics, bind to rRNA in the small subunit of the prokaryotic ribosome. Most aminoglycosides are inactive or weakly active against eukaryotic ribosomes. A major difference in the binding site for these antibiotics between prokaryotic and eukaryotic ribosomes is the identity of the nucleotide at position 1408 (Escherichia coli numbering), ...
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K20 is a novel amphiphilic antifungal aminoglycoside that is synthetically derived from the antibiotic kanamycin A. Reported here are investigations of K20's antimicrobial activities, cytotoxicity, and fungicidal mechanism of action. In vitro growth inhibitory activities against a variety of human and plant pathogenic yeasts, filamentous fungi, and bacteria were determined using microbroth dilu...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 1988
ISSN: 0305-7453,1460-2091
DOI: 10.1093/jac/22.1.1